ea0070aep30 | Adrenal and Cardiovascular Endocrinology | ECE2020
Greenstein Andrew
, Amir Habra Mouhammed
, Mura Marzena
, Biernat Paweł
, Piatek Marek J
, Grauer Andreas
, Peacock Shepherd Stacie
Introduction: Excess glucocorticoid (GC) activity has been implicated in the pathophysiology of multiple cancer types. For instance, approximately half of adrenocortical carcinoma (ACC) patients exhibit excess GC (GC+). This provides a unique opportunity to study correlates of GC activity, such as a possible suppression of tumor immune response and immune checkpoint inhibitor (ICI) efficacy due to the broad immunosuppressive effects of GC. ACC multi-omics data can be used ...